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olorectal cancer, microsatellite instability, African Americans, Caucasians and Hispanicsa. We used random effect meta-analysis to calculate the MSI frequency in all studies as well as in African American and Caucasian samples. Meta-regression analysis was used to assess the univariate effect of race, gender, age, tumor location and stage on MSI frequency. In studies with available race data, The MSI rate among AAs, Hispanics and Caucasians were 12%, 12% and 14% respectively and was not significantly different. Sub-group analysis of studies with racial information indicates MSI OR of 0. 8 for AAs compared to Caucasians. CONCLUSION CRCs demonstrate an overall MSI frequency of 17%. MSI frequency differences between AAs and Caucasians were not pronounced, suggesting that other factors contribute to the racial disparity.

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That would have been an interesting trip to The Wall. On the contrary, Casterly Rock was formerly rich in gold, whereas Highgarden is rich in food (in addition to gold, I'm sure) and is necesary to feed the Lannister army. Casterly Rock was emptied of anything valuable, and the Unsullied are isolated there - sort of a reverse siege. Not only were the Tyrell's her most valuable ally, but the area now serves as a buffer between land-based Dornish forces and the rest of Westeros. The fleet that was going to carry the Dornish was sunk, and if the Dornish invade from the south then they'll have to go through the Reach. It also serves to solidify the other houses formerly loyal to the Tyrells. The houses of the Westerlands aren't going to abandon the Lannisters because they gave away Casterly Rock to a stranded force - but the Tarlys and other houses formerly loyal to the Tyrells were probably going to take up arms against the Crown. In one move, they secure another house's riches to fund the war, secure the best source of food on the continent, shore up the support of the former Tyrell bannermen, neutralize Dany's primary Westerosi ally, isolate her other Westerosi ally, and strand her primary infantry forces - all at the cost of giving away one isolated city temporarily.

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